This landmark article reports on the first successful combined full face and bilateral hand transplant, detailing the surgical planning, multidisciplinary coordination, and postoperative outcomes involved in this unprecedented procedure. The authors outline the technical challenges of simultaneous vascularized composite allotransplantation and discuss functional, aesthetic, and immunologic considerations central to long-term success. The work represents a significant advancement in reconstructive transplantation and highlights the role of innovation, collaboration, and rigorous clinical oversight in pushing the boundaries of reconstructive surgery.